Cranial irradiation in childhood lymphoblastic leukemia: time for reappraisal.
نویسنده
چکیده
I Karmofsky D, Burchenal JH. Clinical evaluation ofchemotherapeutic agents in cancer. In: Macleod CM, ed. Evaluation ofchemotherapeutic agents. New York: Columbia University Press, 1949. 2 Hunt SM, McEwen J, McKenna SP. Measuring health status: a new tool for clinicians and epidemiologists. J R Coll Gen Pract 1985;35:185-8. 3 Grogono AW, Woodgate DJ. Index for measuring health. Lancet 1971 ;ii: 1024-6. 4 Fayers PM, Jones DR. Measuring and analysing quality of life in cancer clinical trials: a review. Statistics in medtcine. Vol 2. Bristol: John Wiley and Sons Ltd, 1983:42946. 5 Steinburg MD, Juliano MA, Wise L. Psychological outcome of lurnpectomy versus mastectomy in the treatment of breast cancer. Amj Psychiatry 1985;142:34-9. 6 Priestman TJ, Baum M. Evaluation of quality of life in patients receiving treatment for advanced breast cancer. Lancet 1976;i:899-901. 7 Spitzer WO, Dobson AJ, Hall J, et al. Measuring the quality of life of cancer patients. J Chronic Dis 1981;34:585-97.
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عنوان ژورنال:
- British medical journal
دوره 291 6497 شماره
صفحات -
تاریخ انتشار 1985